https://mcpress.mayoclinic.org/livi...t-resistant-depression-what-you-need-to-know/
https://www.hopkinsmedicine.org/new...or-up-to-a-year-for-most-patients-study-shows
https://psychedelic.support/resources/mdma-assisted-therapy-guide/
I offer the above links. Ketamine treatments were all the rage, somewhat recently. I personally wouldn't consider any of these treatments; but, my circumstances are different. You can look into them, and research further, if you like. I'm not saying any of the above is a definitive answer to, persistent despair; but, they are certainly options that have not historically been available to most people, especially under optimal conditions. Most psychiatrists will either put you on SSRI's and then just shock your brain (barbaric in my opinion), if the drugs don't work. F that..
What people often fail to realize, is that, there are, literal, and actual cures, for a lot of conditions. It's just that circumstances, may prevent them from...
-Finding the right doctor who is actually knowledgeable
-Having the finances available to actually pay for an optimal treatment
-Cultural or social stigmas
-Being stuck in a circumstance or situation (which may be all the problem is, yet there is absolutely no way out, or at least no way out by one's own accord)
I read a short story in one of those, 'Chicken Soup for the Soul,' books. In this particular story, this woman, who was married, had been depressed for years. Her and her hubs went out for a trip in the Recreational Vehicle, and at one of the campsites, they met some folks. The wife of the people they met, somehow felt, this box she had (I forget what was in the box, some kind of oriental painting supplies or something) was, 'meant,' for her (the depressed wife). And somehow this act of giving, and the gift itself, just turned something on inside of her. She became passionately obsessed with it's contents, it's history, the art that was involved with it. Basically she found a new passion, and it lit up her life, and she was no longer depressed.
So, it's my belief, that, we get, 'stuck,' in life sometimes. And part of what keeps us stuck, unfortunately, is just circumstance. And then, I believe, sometimes we can end up stuck, for so long, or so acutely, that we forget, or are unaware of what is keeping us stuck; and it becomes this puzzling situation, of which, no answer can be found. Sort of like a person who says, 'I have this habit of continually bumping into things.' And they explain this to everyone they know on the internet, but, none of the advice/solutions work. But one day, some one comes over to their house, and realizes, they never turn on the lights. Then some one turns the light on, without thinking much about it, and the person suffering from bumping into things, realizes, OH YEAH!! THE LIGHTS!! I can see better now, so I can avoid bumping into honeysuckle all the time!
Weird stuff like that. It's absolutely unbelievably astounding, in my estimation, the amount of queer, unusual, and unnecessary suffering that goes on in this world, due to circumstance.
We just can't know what we don't know, until we learn about it, or realize it. And sometimes, answers are right in front of our faces, but, we can't see them, due to fear, ignorance, old patterns of thinking, closed mindedness, circumstance, lack of money, etc...
It's really weird... I sometimes wonder if so very many of us in this world, haven't some how been convinced at an early age, that to suffer, is a dutiful thing to do, simply because our parents suffered in their ignorance, and their parents before them did as well, and therefore we must suffer the same ignorance, not because we don't know better, but simply because, we have to, because they had to, and they feel we should as well. It's a bit more complicated than that, but, simply put, it seems to be that way sometimes.
As if millions of people were living out their lives in grocery stores, and starving, simply because those who had gone before them, didn't have such abundance of food, and are taught, or have it forced upon them, that it's their duty to starve, despite food being plentiful and right in front of them...