There's a lot that I like, but the one I've played the last several times is just called Lord of the Rings. It's one of those where it's the players against the game, you have to pool your resources, buff each other up, and try to anticipate what situations the cards will throw at you as you collect tokens and move through the lands of Middle-Earth to destroy the Ring. It's pretty challenging, and has cool artwork.
What is your favorite fictional character (and what do you like about them)?